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Target
Adenosine receptor A1
Ligand
BDBM50168107
Substrate
n/a
Meas. Tech.
ChEMBL_1575938 (CHEMBL3802561)
IC50
152±n/a nM
Citation
 Squarcialupi, L; Falsini, M; Catarzi, D; Varano, F; Betti, M; Varani, K; Vincenzi, F; Dal Ben, D; Lambertucci, C; Volpini, R; Colotta, V Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. Bioorg Med Chem 24:2794-808 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50168107
Synonyms:
CHEMBL3798754
Type:
Small organic molecule
Emp. Form.:
C17H15N5O
Mol. Mass.:
305.3339
SMILES:
Cc1ccc(o1)-c1nc(N)c2nn(Cc3ccccc3)cc2n1
Structure:
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