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Target
Testis-specific serine/threonine-protein kinase 1
Ligand
BDBM2579
Substrate
n/a
Meas. Tech.
ChEMBL_1577793 (CHEMBL3807900)
IC50
0.330000±n/a nM
Citation
 Zhan, W; Xu, L; Dong, X; Dong, J; Yi, X; Ma, X; Qiu, N; Li, J; Yang, B; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors. Eur J Med Chem 117:47-58 (2016) [PubMed]  Article 
Target
Name:
Testis-specific serine/threonine-protein kinase 1
Synonyms:
Serine/threonine-protein kinase 22A | Stk22a | Stk22a | TSK-1 | TSK1 | TSSK-1 | TSSK1_MOUSE | Testis-specific kinase 1 | Testis-specific serine/threonine-protein kinase 1 | Tssk1 | Tssk1b
Type:
PROTEIN
Mol. Mass.:
41594.08
Organism:
Mus musculus
Description:
ChEMBL_116792
Residue:
365
Sequence:
MDDAAVLKRRGYIMGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHRSIVKTYEIFETSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYRMLQPDVNRRLHIDEILNHCWVQPKARGLSSGAINKEGESSRATEPSWIPEPGADKKSATKLEPREEARSEARSESKPQEDTLQVVRQSENVGLSSELNRDTEEGHPQQPSETHT
  
Inhibitor
Name:
BDBM2579
Synonyms:
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | CHEMBL388978 | Staurosporin, 4 | Staurosporine | Staurosporine, 8 | US20240002365, Compound staurosporine | US9206188, Staurosporine | US9226923, Staurosporine
Type:
Small organic molecule
Emp. Form.:
C28H26N4O3
Mol. Mass.:
466.531
SMILES:
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Structure:
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