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Target
M-phase inducer phosphatase 1
Ligand
BDBM50174564
Substrate
n/a
Meas. Tech.
ChEMBL_1580591 (CHEMBL3810599)
IC50
7800±n/a nM
Citation
 Huber-Villaume, S; Revelant, G; Sibille, E; Philippot, S; Morabito, A; Dunand, S; Chaimbault, P; Bagrel, D; Kirsch, G; Hesse, S; Schohn, H 2-(Thienothiazolylimino)-1,3-thiazolidin-4-ones inhibit cell division cycle 25 A phosphatase. Bioorg Med Chem 24:2920-2928 (2016) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50174564
Synonyms:
CHEMBL3808579
Type:
Small organic molecule
Emp. Form.:
C21H11ClFN3OS3
Mol. Mass.:
471.978
SMILES:
Fc1ccc(\C=C2\S\C(NC2=O)=N/c2nc3cc(sc3s2)-c2ccc(Cl)cc2)cc1
Structure:
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