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Target
Aurora kinase B
Ligand
BDBM50175308
Substrate
n/a
Meas. Tech.
ChEMBL_1581135 (CHEMBL3813580)
IC50
600±n/a nM
Citation
 An, Y; Lee, E; Yu, Y; Yun, J; Lee, MY; Kang, JS; Kim, WY; Jeon, R Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors. Bioorg Med Chem Lett 26:3067-72 (2016) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50175308
Synonyms:
CHEMBL3808793
Type:
Small organic molecule
Emp. Form.:
C27H27Cl2N5O4
Mol. Mass.:
556.44
SMILES:
Clc1ccc(NC(=O)Nc2ccc(CNc3nc4ccc(OCCN5CCOCC5)cc4o3)cc2)cc1Cl
Structure:
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