Target
Serine/threonine-protein kinase PAK 1
Ligand
BDBM50181452
Substrate
n/a
Meas. Tech.
ChEBML_1584620
Ki
11±n/a nM
Citation
 Rudolph, JMurray, LJNdubaku, COO'Brien, TBlackwood, EWang, WAliagas, IGazzard, LCrawford, JJDrobnick, JLee, WZhao, XHoeflich, KPFavor, DADong, PZhang, HHeise, CEOh, AOng, CCLa, HChakravarty, PChan, CJakubiak, DEpler, JRamaswamy, SVega, RCain, GDiaz, DZhong, Y Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem 59:5520-41 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 1
Synonyms:
2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK
Type:
n/a
Mol. Mass.:
60640.15
Organism:
Homo sapiens (Human)
Description:
Q13153
Residue:
545
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
  
Inhibitor
Name:
BDBM50181452
Synonyms:
CHEMBL3819118
Type:
Small organic molecule
Emp. Form.:
C26H27ClN6O3
Mol. Mass.:
506.984
SMILES:
CCc1cccn(-c2ccc(c(Cl)c2)-c2cc3cnc(NC)nc3n(C[C@H]3CNCCO3)c2=O)c1=O |r|
Structure:
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