Target
C-X-C chemokine receptor type 2
Ligand
BDBM50182254
Substrate
n/a
Meas. Tech.
ChEMBL_1585799 (CHEMBL3821596)
IC50
2.0±n/a nM
Citation
 Xu, HLu, HXu, ZLuan, LLi, CXu, YDong, KZhang, JLi, XLi, YLiu, GGong, SZhao, YGLiu, AZhang, YZhang, WCai, XXiang, JNElliott, JDLin, X Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett 7:397-402 (2016) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50182254
Synonyms:
CHEMBL3819292
Type:
Small organic molecule
Emp. Form.:
C13H10Cl3N3O4S
Mol. Mass.:
410.66
SMILES:
NS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(Cl)c2Cl)c1O
Structure:
Search PDB for entries with ligand similarity: