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Target
Bcl-2-like protein 1
Ligand
BDBM50189877
Substrate
n/a
Meas. Tech.
ChEMBL_1590437 (CHEMBL3830807)
Ki
8400±n/a nM
Citation
 Yang, C; Chen, H; Lu, S; Zhang, M; Tian, W; Wang, M; Zhang, L; Song, Y; Shen, A; Zhou, Y; Zhu, J; Zheng, C Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity. Bioorg Med Chem Lett 26:3464-7 (2016) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50189877
Synonyms:
CHEMBL3828618
Type:
Small organic molecule
Emp. Form.:
C22H16O6
Mol. Mass.:
376.3588
SMILES:
Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)cc1Cc1ccccc1
Structure:
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