Reaction Details Report a problem with these data
Target
Endoplasmic reticulum aminopeptidase 2
Ligand
BDBM50025049
Substrate
n/a
Meas. Tech.
ChEBML_1591204
Ki
>250000±n/a nM
Citation
 Weglarz-Tomczak, E; Vassiliou, S; Mucha, A Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg Med Chem Lett 26:4122-6 (2016) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum aminopeptidase 2
Synonyms:
Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP
Type:
PROTEIN
Mol. Mass.:
110463.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473169
Residue:
960
Sequence:
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
  
Inhibitor
Name:
BDBM50025049
Synonyms:
CHEMBL3355107
Type:
Small organic molecule
Emp. Form.:
C21H28NO4P
Mol. Mass.:
389.4251
SMILES:
Cc1cc(C)cc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Structure:
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