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Target
Large neutral amino acids transporter small subunit 3
Ligand
BDBM50190653
Substrate
n/a
Meas. Tech.
ChEMBL_1612369 (CHEMBL3854169)
IC50
15500±n/a nM
Citation
 Wibowo, M; Levrier, C; Sadowski, MC; Nelson, CC; Wang, Q; Holst, J; Healy, PC; Hofmann, A; Davis, RA Bioactive Dihydro-ß-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis. J Nat Prod 79:1445-53 (2016) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 3
Synonyms:
L-type amino acid transporter 3 | LAT3 | LAT3_HUMAN | Large neutral amino acids transporter small subunit 3 | PB39 | POV1 | Prostate cancer overexpressed gene 1 protein | SLC43A1 | Solute carrier family 43 member 1 | Synonyms=LAT3
Type:
PROTEIN
Mol. Mass.:
61481.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100162
Residue:
559
Sequence:
MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA
  
Inhibitor
Name:
BDBM50190653
Synonyms:
CHEMBL3959689
Type:
Small organic molecule
Emp. Form.:
C28H36O9
Mol. Mass.:
516.58
SMILES:
[H][C@@]12[C@@H](OC(C)=O)[C@]3(OC1(C)C)[C@H](C)CC[C@H](OC(C)=O)[C@@]3(C)[C@H](OC(=O)c1ccccc1)[C@@H]2OC(C)=O |r|
Structure:
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