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Target
Chromobox protein homolog 5
Ligand
BDBM50194252
Substrate
n/a
Meas. Tech.
ChEMBL_1616626 (CHEMBL3858695)
IC50
>60000±n/a nM
Citation
 Stuckey, JI; Simpson, C; Norris-Drouin, JL; Cholensky, SH; Lee, J; Pasca, R; Cheng, N; Dickson, BM; Pearce, KH; Frye, SV; James, LI Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains. J Med Chem 59:8913-8923 (2016) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 5
Synonyms:
Antigen p25 | CBX5 | CBX5_HUMAN | Chromobox protein homolog 5 | HP1 alpha | HP1A | Heterochromatin protein 1 homolog alpha
Type:
PROTEIN
Mol. Mass.:
22222.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116826
Residue:
191
Sequence:
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
  
Inhibitor
Name:
BDBM50194252
Synonyms:
CHEMBL3922982
Type:
Small organic molecule
Emp. Form.:
C46H65N7O10
Mol. Mass.:
876.0492
SMILES:
COC(=O)[C@H](CO)NC(=O)[C@H](CCCCN(C1CC2CCC1C2)C(C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c1ccccc1 |r|
Structure:
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