Reaction Details Report a problem with these data
Target
Death-associated protein kinase 2
Ligand
BDBM50198027
Substrate
n/a
Meas. Tech.
ChEMBL_1620447 (CHEMBL3862730)
Kd
450±n/a nM
Citation
 Kilchmann, F; Marcaida, MJ; Kotak, S; Schick, T; Boss, SD; Awale, M; Gönczy, P; Reymond, JL Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J Med Chem 59:7188-211 (2016) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 2
Synonyms:
DAP kinase 2 | DAP-kinase-related protein 1 | DAPK2 | DAPK2_HUMAN | DRP-1
Type:
PROTEIN
Mol. Mass.:
42900.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774557
Residue:
370
Sequence:
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
  
Inhibitor
Name:
BDBM50198027
Synonyms:
CHEMBL3921246
Type:
Small organic molecule
Emp. Form.:
C24H21N5O3S
Mol. Mass.:
459.52
SMILES:
CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cn3)C(O)=O)c2)C(=O)N1C
Structure:
Search PDB for entries with ligand similarity: