Target
Outer membrane protein MIP
Ligand
BDBM50200319
Substrate
n/a
Meas. Tech.
ChEMBL_1622004 (CHEMBL3864356)
IC50
11400±n/a nM
Citation
 Seufert, FKuhn, MHein, MWeiwad, MVivoli, MNorville, IHSarkar-Tyson, MMarshall, LESchweimer, KBruhn, HRösch, PHarmer, NJSotriffer, CAHolzgrabe, U Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem 24:5134-5147 (2016) [PubMed]  Article 
Target
Name:
Outer membrane protein MIP
Synonyms:
MIP_LEGPN | Macrophage infectivity potentiator | PPIase | Peptidyl-prolyl cis-trans isomerase | Rotamase | mip
Type:
PROTEIN
Mol. Mass.:
24869.94
Organism:
Legionella pneumophila
Description:
ChEMBL_701873
Residue:
233
Sequence:
MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
  
Inhibitor
Name:
BDBM50200319
Synonyms:
CHEMBL3902318
Type:
Small organic molecule
Emp. Form.:
C21H25N3O5S
Mol. Mass.:
431.505
SMILES:
O=C(OCCNC(=O)c1cccnc1)[C@@H]1CCCCN1S(=O)(=O)Cc1ccccc1 |r|
Structure:
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