Reaction Details Report a problem with these data
Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM50204544
Substrate
n/a
Meas. Tech.
ChEMBL_1627486 (CHEMBL3870007)
IC50
2800±n/a nM
Citation
 Azimi, I; Flanagan, JU; Stevenson, RJ; Inserra, M; Vetter, I; Monteith, GR; Denny, WA Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem 25:440-449 (2017) [PubMed]  Article 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM50204544
Synonyms:
CHEMBL262766
Type:
Small organic molecule
Emp. Form.:
C15H9F6N5OS
Mol. Mass.:
421.32
SMILES:
Cc1nnsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: