Reaction Details
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Calcium release-activated calcium channel protein 1
Ligand
BDBM50204538
Substrate
n/a
Meas. Tech.
ChEMBL_1627484 (CHEMBL3870005)
IC50
42000±n/a nM
Citation
Azimi, I; Flanagan, JU; Stevenson, RJ; Inserra, M; Vetter, I; Monteith, GR; Denny, WA Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem 25:440-449 (2017) [PubMed] Article More Info.:
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
Inhibitor
Name:
BDBM50204538
Synonyms:
CHEMBL3913392
Type:
Small organic molecule
Emp. Form.:
C23H28N2O3
Mol. Mass.:
380.48
SMILES:
COc1ccc(CCCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1
Structure:
