Reaction Details Report a problem with these data
Target
Thioredoxin reductase
Ligand
BDBM50375309
Substrate
n/a
Meas. Tech.
ChEMBL_1629022 (CHEMBL3871648)
Ki
3300±n/a nM
Citation
 Ansari, MF; Siddiqui, SM; Ahmad, K; Avecilla, F; Dharavath, S; Gourinath, S; Azam, A Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. Eur J Med Chem 124:393-406 (2016) [PubMed]  Article 
Target
Name:
Thioredoxin reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
33740.27
Organism:
Entamoeba histolytica
Description:
ChEMBL_116971
Residue:
314
Sequence:
MSNIHDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGGVAAGGQLTTTTIIENFPGFPNGIDGNELMMNMRTQSEKYGTTIITETIDHVDFSTQPFKLFTEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQNGVSACAICDGAVPIFRNKVLMVVGGGDAAMEEALHLTKYGSKVIILHRRDAFRASKTMQERVLNHPKIEVIWNSELVELEGDGDLLNGAKIHNLVSGEYKVVPVAGLFYAIGHSPNSKFLGGQVKTADDGYILTEGPKTSVDGVFACGDVCDRVYRQAIVAAGSGCMAALSCEKWLQTH
  
Inhibitor
Name:
BDBM50375309
Synonyms:
BAY-5360 | Flagyl | Flagyl 375 | Flagyl ER | Flagyl i.v. rtu in plastic container | METRONIDAZOLE | Metric 21 | Metro IV | Metro i.v. | MetroGel | Metrocream | Metrogel-vaginal | Metrolotion | Metrolyl | Metromidol
Type:
Small organic molecule
Emp. Form.:
C6H9N3O3
Mol. Mass.:
171.154
SMILES:
Cc1ncc(n1CCO)[N+]([O-])=O
Structure:
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