Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50206719
Substrate
n/a
Meas. Tech.
ChEMBL_1629231 (CHEMBL3871857)
Ki
0.630957±n/a nM
Citation
 Schrader, TO; Kasem, M; Ren, A; Feichtinger, K; Al Doori, B; Wei, J; Wu, C; Dang, H; Le, M; Gatlin, J; Chase, K; Dong, J; Whelan, KT; Sage, C; Grottick, AJ; Semple, G Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT Bioorg Med Chem Lett 26:5877-5882 (2016) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50206719
Synonyms:
CHEMBL3956394
Type:
Small organic molecule
Emp. Form.:
C19H21FN2
Mol. Mass.:
296.3818
SMILES:
Fc1ccc2N3CCNCC3CCc2c1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: