Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50208213
Substrate
n/a
Meas. Tech.
ChEMBL_1632480 (CHEMBL3875272)
Ki
16±n/a nM
Citation
 Wieckowska, A; Kolaczkowski, M; Bucki, A; Godyn, J; Marcinkowska, M; Wieckowski, K; Zareba, P; Siwek, A; Kazek, G; Gluch-Lutwin, M; Mierzejewski, P; Bienkowski, P; Sienkiewicz-Jarosz, H; Knez, D; Wichur, T; Gobec, S; Malawska, B Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT Eur J Med Chem 124:63-81 (2016) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50208213
Synonyms:
CHEMBL3884254
Type:
Small organic molecule
Emp. Form.:
C34H44ClN5O2S
Mol. Mass.:
622.263
SMILES:
Cl.O=S(=O)(c1ccccc1)n1ccc2c(cccc12)N1CCN(CCCCNC2CCN(Cc3ccccc3)CC2)CC1
Structure:
Search PDB for entries with ligand similarity: