Reaction Details
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Free fatty acid receptor 1
Ligand
BDBM50210157
Substrate
n/a
Meas. Tech.
ChEMBL_1634352 (CHEMBL3877144)
EC50
16±n/a nM
Citation
Plummer, CW; Clements, MJ; Chen, H; Rajagopalan, M; Josien, H; Hagmann, WK; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Nolting, AF; Orr, R; Christensen, M; Campeau, LC; Wright, MJ; Bugianesi, R; Souza, S; Zhang, X; Di Salvo, J; Weinglass, AB; Tschirret-Guth, R; Nargund, R; Howard, AD; Colletti, SL Design and Synthesis of Novel, Selective GPR40 AgoPAMs. ACS Med Chem Lett 8:221-226 (2017) [PubMed] Article More Info.:
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Inhibitor
Name:
BDBM50210157
Synonyms:
CHEMBL3883790
Type:
Small organic molecule
Emp. Form.:
C27H26FNO4
Mol. Mass.:
447.498
SMILES:
COc1ccc(F)c(c1)-c1ccc(nc1)C1CCc2ccc(cc2O1)[C@@H](CC(O)=O)C1CC1 |r|
Structure:
