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TargetAdenosine receptor A1
LigandBDBM50210817
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1635279
Ki 1.1±n/a nM
Citation Alachouzos, GLenselink, EBMulder-Krieger, Tde Vries, HIJzerman, APLouvel, J Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A Eur J Med Chem125:586-602 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A1
Name:Adenosine receptor A1/Alpha-2A adrenergic receptor
Synonyms:A1 adenosine receptor (hA1) | A1AR | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:36520.92
Organism:Homo sapiens (Human)
Description:P30542
Residue:326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50210817
NameBDBM50210817
Synonyms:CHEMBL3966761
TypeSmall organic molecule
Emp. Form.C24H26N4O
Mol. Mass.386.4894
SMILESO[C@H]1CC[C@@H](CC1)Nc1ncc(-c2ccnc(c2)C2CC2)c(n1)-c1ccccc1 |r,wU:4.7,wD:1.0,(24.41,-7.47,;23.08,-8.25,;21.74,-7.49,;20.41,-8.27,;20.43,-9.81,;21.77,-10.57,;23.09,-9.79,;19.1,-10.59,;19.11,-12.13,;20.45,-12.9,;20.46,-14.44,;19.13,-15.21,;19.14,-16.75,;17.82,-17.53,;17.84,-19.07,;19.17,-19.83,;20.5,-19.06,;20.48,-17.52,;21.84,-19.81,;22.62,-21.13,;23.38,-19.79,;17.8,-14.45,;17.79,-12.91,;16.47,-15.24,;15.12,-14.48,;13.8,-15.25,;13.81,-16.79,;15.15,-17.56,;16.48,-16.78,)|
Structure
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