Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50213876
Substrate
n/a
Meas. Tech.
ChEBML_85064
IC50
442±n/a nM
Citation
  TBA Bioorg Med Chem Lett 6:1795-1798 (1996)   
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40567.22
Organism:
Cavia porcellus (domestic guinea pig)
Description:
For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:
359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
  
Inhibitor
Name:
BDBM50213876
Synonyms:
CHEMBL50524
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3S
Mol. Mass.:
361.459
SMILES:
Nc1c(NC\C=C/COc2csc(CN3CCCCC3)c2)c(=O)c1=O
Structure:
Search PDB for entries with ligand similarity: