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Target
Glycylpeptide N-tetradecanoyltransferase 1/2
Ligand
BDBM50109879
Substrate
n/a
Meas. Tech.
ChEMBL_141126 (CHEMBL882639)
IC50
3.7±n/a nM
Citation
 Ebiike, H; Masubuchi, M; Liu, P; Kawasaki, K; Morikami, K; Sogabe, S; Hayase, M; Fujii, T; Sakata, K; Shindoh, H; Shiratori, Y; Aoki, Y; Ohtsuka, T; Shimma, N Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. Bioorg Med Chem Lett 12:607-10 (2002) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1/2
Synonyms:
Peptide N-myristoyltransferase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 141178
Components:
This complex has 2 components.
Component 1
Name:
Glycylpeptide N-tetradecanoyltransferase 2
Synonyms:
Glycylpeptide N-tetradecanoyltransferase 2 | Myristoyl-CoA:protein N-myristoyltransferase 2 | NMT 2 | NMT2 | NMT2_HUMAN | Peptide N-myristoyltransferase 2 | Type II N-myristoyltransferase
Type:
PROTEIN
Mol. Mass.:
56986.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435042
Residue:
498
Sequence:
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
  
Component 2
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50109879
Synonyms:
CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluoro-phenoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine
Type:
Small organic molecule
Emp. Form.:
C25H24F2N2O3
Mol. Mass.:
438.4665
SMILES:
Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Structure:
Search PDB for entries with ligand similarity: