Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50146017
Substrate
n/a
Meas. Tech.
ChEMBL_211665 (CHEMBL821417)
Ki
100000±n/a nM
Citation
 Zavala, F; Guenard, D; Robin, JP; Brown, E Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin. J Med Chem 23:546-9 (1980) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50146017
Synonyms:
CHEMBL152476
Type:
Small organic molecule
Emp. Form.:
C22H22O7
Mol. Mass.:
398.4059
SMILES:
[H][C@@]12COC(=O)[C@@]1([H])Cc1cc(OC)c(OC)c(OC)c1-c1cc3OCOc3cc1C2
Structure:
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