Reaction Details Report a problem with these data
Target
Adenylate cyclase type 1
Ligand
BDBM50222265
Substrate
n/a
Meas. Tech.
ChEMBL_31583 (CHEMBL646377)
Ki
250±n/a nM
Citation
 Kaiser, C; Ali, FE; Bondinell, WE; Brenner, M; Holden, KG; Ku, TW; Oh, HJ; Ross, ST; Yim, NC; Zirkle, CL; Hahn, RA; Sarau, HM; Setler, PE; Wardell, JR 6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics. J Med Chem 23:975-6 (1980) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 1
Synonyms:
4.6.1.1 | Adcy1 | Adenylate cyclase | Synonyms=Adcy1_predicted
Type:
PROTEIN
Mol. Mass.:
108287.66
Organism:
Rattus norvegicus
Description:
ChEMBL_104763
Residue:
967
Sequence:
MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVLPALPCESAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGSSSHSRSLRLERRMFPYGRGGGGQARRPPLCPAAGPPIKPGLSPAPTSQYLSSTAAGKEA
  
Inhibitor
Name:
BDBM50222265
Synonyms:
CHEMBL541633
Type:
Small organic molecule
Emp. Form.:
C16H18BrNO2S
Mol. Mass.:
368.289
SMILES:
Br.Oc1cc2CCNCCc2c(Sc2ccccc2)c1O
Structure:
Search PDB for entries with ligand similarity: