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Reaction Details
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TargetDihydrofolate reductase
LigandBDBM50405976
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54733
Ki 95±n/a nM
Citation Li, RLDietrich, SWHansch, C Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines. J Med Chem24:538-44 (1981) [PubMed]  Article
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (F31V) | dfrA17
Type:n/a
Mol. Mass.:17532.46
Organism:Escherichia coli
Description:n/a
Residue:157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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BDBM50405976
NameBDBM50405976
Synonyms:CHEMBL19790
TypeSmall organic molecule
Emp. Form.C12H11F3N4
Mol. Mass.268.2377
SMILESNc1ncc(Cc2cccc(c2)C(F)(F)F)c(N)n1
Structure
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n/a