Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50405984
Substrate
n/a
Meas. Tech.
ChEMBL_53618 (CHEMBL663687)
pH
7.2±n/a
Ki
46774±n/a nM
Comments
extracted
Citation
 Li, R; Hansch, C; Kaufman, BT A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver. J Med Chem 25:435-40 (1982) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50405984
Synonyms:
CHEMBL434787
Type:
Small organic molecule
Emp. Form.:
C12H14N4O3S
Mol. Mass.:
294.33
SMILES:
CS(=O)(=O)Oc1cccc(Cc2cnc(N)nc2N)c1
Structure:
Search PDB for entries with ligand similarity: