Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50405962
Substrate
n/a
Meas. Tech.
ChEMBL_53618 (CHEMBL663687)
pH
7.2±n/a
Ki
19953±n/a nM
Comments
extracted
Citation
 Li, R; Hansch, C; Kaufman, BT A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver. J Med Chem 25:435-40 (1982) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50405962
Synonyms:
CHEMBL19772
Type:
Small organic molecule
Emp. Form.:
C11H11FN4
Mol. Mass.:
218.2302
SMILES:
Nc1ncc(Cc2cccc(F)c2)c(N)n1
Structure:
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