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Target
Sterol O-acyltransferase 1
Ligand
BDBM50227948
Substrate
n/a
Meas. Tech.
ChEMBL_28503 (CHEMBL645932)
IC50
3180±n/a nM
Citation
 DeVries, VG; Bloom, JD; Dutia, MD; Katocs, AS; Largis, EE Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues. J Med Chem 32:2318-25 (1989) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50227948
Synonyms:
CHEMBL75596
Type:
Small organic molecule
Emp. Form.:
C27H24N2O2
Mol. Mass.:
408.4917
SMILES:
O=C(Nc1ccc(Oc2ccccc2)cc1)N(Cc1ccccc1)Cc1ccccc1
Structure:
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