Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50228825
Substrate
n/a
Meas. Tech.
ChEMBL_40449 (CHEMBL652387)
IC50
10.0±n/a nM
Citation
 Saccomano, NA; Vinick, FJ; Koe, BK; Nielsen, JA; Whalen, WM; Meltz, M; Phillips, D; Thadieo, PF; Jung, S; Chapin, DS Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones. J Med Chem 34:291-8 (1991) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50228825
Synonyms:
CHEMBL2112409
Type:
Small organic molecule
Emp. Form.:
C21H28N2O3
Mol. Mass.:
356.4586
SMILES:
COc1ccc(cc1O[C@@H]1CC2CC1C1CCCC21)C1CNC(=O)N1C |r,TLB:15:14:12:9.10,8:9:12:14.18,THB:17:18:12:9.10|
Structure:
Search PDB for entries with ligand similarity: