Reaction Details Report a problem with these data
Target
Sialic acid-binding Ig-like lectin 7
Ligand
BDBM50230580
Substrate
n/a
Meas. Tech.
ChEMBL_1644940 (CHEMBL3993869)
IC50
53000±n/a nM
Citation
 Prescher, H; Frank, M; Gütgemann, S; Kuhfeldt, E; Schweizer, A; Nitschke, L; Watzl, C; Brossmer, R Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion. J Med Chem 60:941-956 (2017) [PubMed]  Article 
Target
Name:
Sialic acid-binding Ig-like lectin 7
Synonyms:
AIRM-1 | AIRM1 | Adhesion inhibitory receptor molecule 1 | CD_antigen=CD328 | CDw328 | D-siglec | QA79 membrane protein | SIGL7_HUMAN | SIGLEC7 | Sialic acid-binding Ig-like lectin 7 | Siglec-7 | p75
Type:
PROTEIN
Mol. Mass.:
51147.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109858
Residue:
467
Sequence:
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
  
Inhibitor
Name:
BDBM50230580
Synonyms:
CHEMBL4094130
Type:
Small organic molecule
Emp. Form.:
C28H33N4NaO9
Mol. Mass.:
592.5728
SMILES:
[Na+].[H][C@]1(O[C@@](C[C@H](O)[C@H]1NC(C)=O)(OCCCn1cc(nn1)-c1ccc(cc1)-c1ccccc1)C([O-])=O)[C@H](O)[C@H](O)CO |r|
Structure:
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