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Target
Proteasome subunit beta type-9
Ligand
BDBM50232675
Substrate
n/a
Meas. Tech.
ChEMBL_1648454 (CHEMBL3997510)
IC50
51±n/a nM
Citation
 Johnson, HWB; Anderl, JL; Bradley, EK; Bui, J; Jones, J; Arastu-Kapur, S; Kelly, LM; Lowe, E; Moebius, DC; Muchamuel, T; Kirk, C; Wang, Z; McMinn, D Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. ACS Med Chem Lett 8:413-417 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50232675
Synonyms:
CHEMBL4100295
Type:
Small organic molecule
Emp. Form.:
C21H23N3O6
Mol. Mass.:
413.4238
SMILES:
C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)c1cccc(=O)[nH]1 |r|
Structure:
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