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TargetCytochrome P450 2D6
LigandBDBM50233520
Substrate/Competitorn/a
Meas. Tech.ChEBML_1650996
IC50>100000±n/a nM
Citation Sandham, DABarker, LBrown, LBrown, ZBudd, DCharlton, SJChatterjee, DCox, BDubois, GDuggan, NHall, EHatto, JMaas, JManini, JProfit, RRiddy, DRitchie, CSohal, BShaw, DStringer, RSykes, DAThomas, MTurner, KLWatson, SJWest, RWillard, EWilliams, GWillis, J Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP ACS Med Chem Lett8:582-586 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50233520
NameBDBM50233520
Synonyms:FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039
TypeSmall organic molecule
Emp. Form.C19H17F3N2O4S
Mol. Mass.426.409
SMILESCc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
Structure
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n/a