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TargetProstanoid IP receptor
LigandBDBM50233520
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1650990
EC50>10000±n/a nM
Citation Sandham, DABarker, LBrown, LBrown, ZBudd, DCharlton, SJChatterjee, DCox, BDubois, GDuggan, NHall, EHatto, JMaas, JManini, JProfit, RRiddy, DRitchie, CSohal, BShaw, DStringer, RSykes, DAThomas, MTurner, KLWatson, SJWest, RWillard, EWilliams, GWillis, J Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP ACS Med Chem Lett8:582-586 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostanoid IP receptor
Name:Prostanoid IP receptor
Synonyms:PGI receptor | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40968.22
Organism:Homo sapiens (Human)
Description:The membranes prepared from human platelet were used in binding assay.
Residue:386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50233520
NameBDBM50233520
Synonyms:FEVIPIPRANT | Fevipiprant | NVP-QAW039 | QAW039
TypeSmall organic molecule
Emp. Form.C19H17F3N2O4S
Mol. Mass.426.409
SMILESCc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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