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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM50235196
Substrate
n/a
Meas. Tech.
ChEMBL_1654962 (CHEMBL4004328)
IC50
40±n/a nM
Citation
 Chobanian, HR; Guo, Y; Pio, B; Tang, H; Teumelsan, N; Clements, M; Frie, J; Ferguson, R; Guo, Z; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, B; Hampton, C; Pai, LY; Corona, A; Metzger, J; Tong, V; Joshi, EM; Xu, L; Owens, K; Maloney, K; Sullivan, K; Pasternak, A The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics. Bioorg Med Chem Lett 27:1109-1114 (2017) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-sensitive inward rectifier potassium channel 1 | Inward rectifier K(+) channel Kir1.1 | KAB-1 | KCNJ1_RAT | Kcnj1 | Potassium channel (ATP modulatory) | Potassium channel, inwardly rectifying subfamily J member 1 | Renal Outer Medullary Potassium (ROMK) | Renal Outer Medullary Potassium (ROMK1) | Romk1 | The Renal Outer Medullary Potassium (ROMK) channel (Kir1.1)
Type:
Enzyme
Mol. Mass.:
44976.27
Organism:
Rattus norvegicus (Rat)
Description:
P35560
Residue:
391
Sequence:
MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
  
Inhibitor
Name:
BDBM50235196
Synonyms:
CHEMBL4064760
Type:
Small organic molecule
Emp. Form.:
C24H30N4O5S
Mol. Mass.:
486.584
SMILES:
Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)S(C)(=O)=O)CC1 |r|
Structure:
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