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TargetTyrosine-protein kinase SYK
LigandBDBM50237234
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1660848
IC50 20±n/a nM
Citation Huang, YZhang, YFan, KDong, GLi, BZhang, WLi, JSheng, C Discovery of new Syk inhibitors through structure-based virtual screening. Bioorg Med Chem Lett27:1776-1779 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50237234
NameBDBM50237234
Synonyms:CHEMBL4103500
TypeSmall organic molecule
Emp. Form.C25H28N6O2
Mol. Mass.444.5288
SMILESCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |TLB:21:22:28:25.26.31,30:29:22:25.24.26,THB:24:23:28:25.26.31,24:25:28:22.23.32,31:29:22:25.24.26,31:25:22:29.28.32,(1.65,-17.33,;2.55,-18.58,;2.08,-20.05,;3.32,-20.95,;4.57,-20.05,;4.09,-18.58,;3.32,-22.48,;1.99,-23.25,;1.99,-24.8,;3.33,-25.57,;4.65,-24.8,;4.66,-23.25,;5.98,-25.57,;5.98,-27.11,;7.32,-27.88,;8.66,-27.11,;9.99,-27.88,;8.65,-25.56,;7.31,-24.8,;9.98,-24.78,;11.32,-25.55,;9.97,-23.24,;11.3,-22.47,;12.8,-22.05,;14.21,-22.61,;15.22,-21.34,;13.82,-21.68,;12.5,-21.19,;12.49,-19.7,;13.83,-19.23,;13.82,-17.69,;15.24,-19.81,;12.8,-20.47,)|
Structure
n/a