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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM50237234 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1660848 | ||
| IC50 | 20±n/a nM | ||
| Citation |  Huang, Y; Zhang, Y; Fan, K; Dong, G; Li, B; Zhang, W; Li, J; Sheng, C Discovery of new Syk inhibitors through structure-based virtual screening. Bioorg Med Chem Lett27:1776-1779 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
| ||
| BDBM50237234 | |||
| Name | BDBM50237234 | ||
| Synonyms: | CHEMBL4103500 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N6O2 | ||
| Mol. Mass. | 444.5288 | ||
| SMILES | Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |TLB:21:22:28:25.26.31,30:29:22:25.24.26,THB:24:23:28:25.26.31,24:25:28:22.23.32,31:29:22:25.24.26,31:25:22:29.28.32,(1.65,-17.33,;2.55,-18.58,;2.08,-20.05,;3.32,-20.95,;4.57,-20.05,;4.09,-18.58,;3.32,-22.48,;1.99,-23.25,;1.99,-24.8,;3.33,-25.57,;4.65,-24.8,;4.66,-23.25,;5.98,-25.57,;5.98,-27.11,;7.32,-27.88,;8.66,-27.11,;9.99,-27.88,;8.65,-25.56,;7.31,-24.8,;9.98,-24.78,;11.32,-25.55,;9.97,-23.24,;11.3,-22.47,;12.8,-22.05,;14.21,-22.61,;15.22,-21.34,;13.82,-21.68,;12.5,-21.19,;12.49,-19.7,;13.83,-19.23,;13.82,-17.69,;15.24,-19.81,;12.8,-20.47,)| | ||
| Structure |  | ||
| n/a | |||