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Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM85117
Substrate
n/a
Meas. Tech.
PPIase Assay
Ki
>1.00e+5±n/a nM
Citation
 Dunsmore, CJ; Malone, KJ; Bailey, KR; Wear, MA; Florance, H; Shirran, S; Barran, PE; Page, AP; Walkinshaw, MD; Turner, NJ Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans. Chembiochem 12:802-10 (2011) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM85117
Synonyms:
Cyclophilin Inhibitor, 3c
Type:
Small organic molecule
Emp. Form.:
C18H26N4O6
Mol. Mass.:
394.4222
SMILES:
COC(=O)[C@H](CCCN=C(N)NN(=O)=O)C1C(=O)CC2C1=CC(=O)CC2(C)C |r,w:8.7,t:21|
Structure:
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