Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 6

Ligand

BDBM50027065

Substrate

n/a

2.34±n/a nM

Comments

PDSP_797

Citation

Boess, FG; Monsma, FJ; Carolo, C; Meyer, V; Rudler, A; Zwingelstein, C; Sleight, AJ Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology 36:713-20 (1997) [PubMed] Article

More Info.:

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Target

Name:

5-hydroxytryptamine receptor 6

Synonyms:

5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46945.51

Organism:

RAT

Description:

5-HT6 HTR6 RAT::P31388

Residue:

436

Sequence:

MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP

Inhibitor

Name:

BDBM50027065

Synonyms:

(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione | (5'alpha)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman | 12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione | ERGOTAMINE | Ergotamin

Type:

Small organic molecule

Emp. Form.:

C33H35N5O5

Mol. Mass.:

581.6615

SMILES:

CN1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O |r,c:4|

Structure: