Reaction Details
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Report a problem with these dataTarget
Muscarinic acetylcholine receptor
Ligand
BDBM50015720
Substrate
n/a
Ki
0.21±n/a nM
Comments
PDSP_1688
Citation
Chelala, JL; Kilani, A; Miller, MJ; Martin, RJ; Ernsberger, P Muscarinic receptor binding sites of the M4 subtype in porcine lung parenchyma. Pharmacol Toxicol 83:200-7 (1998) [PubMed] Article More Info.:
Target
Name:
Muscarinic acetylcholine receptor
Synonyms:
CHRM4 | Cholinergic, muscarinic M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50324.85
Organism:
PORCINE
Description:
F1SIA0
Residue:
479
Sequence:
MANVTPVNGSAGNQSVRLVTATHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYVHISLASRSRVHKHRPEGPKEKKAKPLAFLKSPLMKQSVKKPPPGEAAARGELRNGKLEEAPPPVLPPPPRPVADKDTSNESSSGSATQNTKERPPTELSTTEATTPAAPAPPLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
Inhibitor
Name:
BDBM50015720
Synonyms:
(hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester | 3-hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester | 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl 3-hydroxy-2-phenylpropanoate | Benzotropine3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester | CHEMBL13030 | ChEMBL_11434 | SCOPOLAMINE
Type:
Small organic molecule
Emp. Form.:
C17H21NO4
Mol. Mass.:
303.3529
SMILES:
CN1C2CC(CC1C1OC21)OC(=O)C(CO)c1ccccc1 |TLB:8:9:1:3.5.4,8:7:1:3.5.4,0:1:9.7:3.5.4,THB:10:4:9.7:1|
Structure:
