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TargetS-Adenosylmethionine Synthase (AdoMet)
LigandBDBM85451
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.5±0
Temperature310.15±0 K
Ki 140000±0.0 nM
IC50 300000±0.0 nM
Citation Lavrador, KAllart, BGuillerm, DGuillerm, G A new series of S-adenosyl-L-methionine synthetase inhibitors. J Enzym Inhib13:361-7 (1998) [PubMed]
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S-Adenosylmethionine Synthase (AdoMet)
Name:S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Synonyms:AdoMet synthetase 2 | MAT 2 | MAT-II | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:PROTEIN
Mol. Mass.:43713.68
Organism:Rattus norvegicus
Description:ChEMBL_105118
Residue:395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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BDBM85451
NameBDBM85451
Synonyms:Epithioamino acid analogue, II(b)
TypeSmall organic molecule
Emp. Form.C6H11NO2S
Mol. Mass.161.222
SMILESC[C@H]1S[C@@H]1C[C@H](N)C(O)=O |r|
Structure
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n/a