Ki Summary

Reaction Details

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Target

Delta-type opioid receptor

Ligand

BDBM50041958

Substrate

n/a

7060±n/a nM

Comments

PDSP_2917

Citation

Márki, A; Monory, K; Otvös, F; Tóth, G; Krassnig, R; Schmidhammer, H; Traynor, JR; Roques, BP; Maldonado, R; Borsodi, A Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. Eur J Pharmacol 383:209-14 (1999) [PubMed] Article

More Info.:

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Target

Name:

Delta-type opioid receptor

Synonyms:

Delta opioid receptor | Delta-type opioid receptor | OPIATE Delta | OPRD1 | OPRD_PIG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

25736.90

Organism:

GUINEA PIG

Description:

OPIATE Delta OPRD1 GUINEA PIG::P79291

Residue:

228

Sequence:

GIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL

Inhibitor

Name:

BDBM50041958

Synonyms:

2-(1-{2-[2-amino-3-(4-hydroxyphenyl)propanoyl]-1,2,3,4-tetrahydro-3-isoquinolinylmethylamino}-2-phenylethylcarboxamido)-3-phenylpropanoic acid | 2-[1-{2-[2-amino-3-(4-hydroxyphenyl)-(2S)-propanoyl]-1,2,3,4-tetrahydro-3-isoquinolinylcarboxamido}-2-phenyl-(1S)-ethylcarboxamido]-3-phenyl-(2S)-propanoic acid | CHEMBL108731 | TIPP

Type:

Small organic molecule

Emp. Form.:

C37H38N4O6

Mol. Mass.:

634.7208

SMILES:

N[C@@H](Cc1ccc(O)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

Structure: