Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM77842
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
4.9e+4± 2e+3 nM
Citation
 Alagille, D; Pfeiffer, B; Scalbert, E; Ferry, G; Boutin, JA; Renard, P; Viaud-Massuard, MC Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors. J Enzyme Inhib Med Chem 19:137-43 (2004) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM77842
Synonyms:
Tetrahydroisoquinoline hydantoin derivative, 5a
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4S
Mol. Mass.:
356.396
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C(=O)[C@@H]2Cc3ccccc3CN2C1=O
Structure:
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