Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM22911
Substrate
n/a
Ki
0.3±n/a nM
Comments
PDSP_968
Citation
 Liu, C; Ma, X; Jiang, X; Wilson, SJ; Hofstra, CL; Blevitt, J; Pyati, J; Li, X; Chai, W; Carruthers, N; Lovenberg, TW Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol 59:420-6 (2001) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM22911
Synonyms:
2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide | CHEMBL19439 | CHEMBL544911 | Imetit | {[2-(1H-imidazol-4-yl)ethyl]sulfanyl}methanimidamide
Type:
Small organic molecule
Emp. Form.:
C6H10N4S
Mol. Mass.:
170.235
SMILES:
NC(=N)SCCc1cnc[nH]1
Structure:
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