Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50022784
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_3689
Citation
 Bymaster, FP; Katner, JS; Nelson, DL; Hemrick-Luecke, SK; Threlkeld, PG; Heiligenstein, JH; Morin, SM; Gehlert, DR; Perry, KW Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27:699-711 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_BOVIN | ADENOSINE A2 | ADORA2B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36398.35
Organism:
BOVINE
Description:
ADENOSINE A2 0 BOVINE::Q1LZD0
Residue:
332
Sequence:
MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISRYILCRTHILKSGEGQVGSQPTLQLGL
  
Inhibitor
Name:
BDBM50022784
Synonyms:
(R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine | ATOMOXETINE | CHEMBL641 | Methyl-((R)-3-phenyl-3-o-tolyloxy-propyl)-amine | Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine | Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxetine) | Strattera | Tomoxetine
Type:
Small organic molecule
Emp. Form.:
C17H21NO
Mol. Mass.:
255.3547
SMILES:
CNCCC(Oc1ccccc1C)c1ccccc1
Structure:
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