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TargetLipoxygenase
LigandBDBM86074
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±0
Temperature298.15±0 K
IC50 2.13e+4± 0 nM
Citation Maharvi, GMAli, SRiaz, NAfza, NMalik, AAshraf, MIqbal, LLateef, M Mild and efficient synthesis of new tetraketones as lipoxygenase inhibitors and antioxidants. J Enzyme Inhib Med Chem23:62-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Lipoxygenase
Name:Lipoxygenase
Synonyms:n/a
Type:Enzyme
Mol. Mass.:80366.80
Organism:Homo sapiens (Human)
Description:AAC79680.1
Residue:701
Sequence:
MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQD
LGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKT
TADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGY
IPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIR
KIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGE
GTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQ
TPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMC
HPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLY
LPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEI
FKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMR
NPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRR
SIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM86074
NameBDBM86074
Synonyms:Tetraketone, 8
TypeSmall organic molecule
Emp. Form.C24H30O5
Mol. Mass.398.492
SMILESCOc1ccc(cc1)C(C1C(=O)CC(C)(C)CC1=O)C1C(=O)CC(C)(C)CC1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a