Reaction Details Report a problem with these data
Target
Sodium-dependent serotonin transporter
Ligand
BDBM50005247
Substrate
n/a
Ki
160±n/a nM
Comments
PDSP_3076
Citation
 Setola, V; Hufeisen, SJ; Grande-Allen, KJ; Vesely, I; Glennon, RA; Blough, B; Rothman, RB; Roth, BL 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol 63:1223-9 (2003) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50005247
Synonyms:
(+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (R)-(-)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (S)-(+)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine((R)-(-)-MDA) | 3,4-methylenedioxyamphetamine | CHEMBL6731 | MDA | MDA, (R,S) | MDA,R(-) | Tenamfetamine | methylenedioxyamphetamine
Type:
Small organic molecule
Emp. Form.:
C10H13NO2
Mol. Mass.:
179.2157
SMILES:
CC(N)Cc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: