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Target
Sodium-dependent serotonin transporter
Ligand
BDBM84738
Substrate
n/a
Ki
7047±n/a nM
Comments
PDSP_813
Citation
 Li, Q; Ma, L; Innis, RB; Seneca, N; Ichise, M; Huang, H; Laruelle, M; Murphy, DL Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB). J Pharmacol Exp Ther 308:481-6 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | Htt | SC6A4_MOUSE | Serotonin transporter | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70044.92
Organism:
MOUSE
Description:
5-HT Transporter SLC6A4 MOUSE::Q60857
Residue:
630
Sequence:
METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM84738
Synonyms:
CAS_16105-77-4 | Fenfluramine | Fenfluramine (+) | Fenfluramine (-) | NSC_3337 | d-Fenfluramine
Type:
Small organic molecule
Emp. Form.:
C12H16F3N
Mol. Mass.:
231.2573
SMILES:
CCNC(C)Cc1cccc(c1)C(F)(F)F
Structure:
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