Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50171290
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_3734
Citation
 Rinaldi-Carmona, M; Barth, F; Congy, C; Martinez, S; Oustric, D; Pério, A; Poncelet, M; Maruani, J; Arnone, M; Finance, O; Soubrié, P; Le Fur, G SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther 310:905-14 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
ADENOSINE A3 | Adora3 | Adora3 protein | Q497R5_MOUSE
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20065.67
Organism:
Mus musculus
Description:
Q497R5
Residue:
173
Sequence:
MFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFVTWILVPLVVMCVIYLDIFYIIRNKLSQNLSGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRALRLCQTSDSLDSNMEQTTE
  
Inhibitor
Name:
BDBM50171290
Synonyms:
5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide | CHEMBL189676 | SR 147778
Type:
Small organic molecule
Emp. Form.:
C23H23BrCl2N4O
Mol. Mass.:
522.265
SMILES:
CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Structure:
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