Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM86519
Substrate
n/a
Ki
536±n/a nM
Comments
PDSP_3634
Citation
 Gilbert, AK; Hosztafi, S; Mahurter, L; Pasternak, GW Pharmacological characterization of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin analgesia and their differentiation from morphine. Eur J Pharmacol 492:123-30 (2004) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | OPIATE Kappa | OPIATE Kappa 3 | OPRK1 | OPRK_BOVIN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42629.84
Organism:
CALF
Description:
Q2KIP6
Residue:
380
Sequence:
MEPPVQIFRGEPGPTCSPSTCLPPNGSGWFPGWAEPDGNGSAGSEDVLLEPAHISPVILVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKVVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWILSSSVGISAIVLGGTKVREDMEVIECSLQFPDDDYSWWDLFMKVCVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTAHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYVREVDGVNKPV
  
Inhibitor
Name:
BDBM86519
Synonyms:
CAS_11221 | Dihydroheroin | NSC_11221
Type:
Small organic molecule
Emp. Form.:
C21H25NO5
Mol. Mass.:
371.4269
SMILES:
CN1CCC23C4Oc5c2c(CC1C3CCC4OC(C)=O)ccc5OC(C)=O |TLB:13:12:10.9.8:3.2.1|
Structure:
Search PDB for entries with ligand similarity: