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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88875
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
38900±6370 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88875
Synonyms:
(E)-2-Cyano-N-(3-imidazol-1-yl-propyl)-3-[3-(3-methoxy-phenyl)-1-phenyl-1H-pyrazol-4-yl]-acrylamide | (E)-2-cyano-N-(3-imidazol-1-ylpropyl)-3-[3-(3-methoxyphenyl)-1-phenyl-pyrazol-4-yl]acrylamide | (E)-2-cyano-N-(3-imidazol-1-ylpropyl)-3-[3-(3-methoxyphenyl)-1-phenyl-pyrazol-4-yl]prop-2-enamide | (E)-2-cyano-N-(3-imidazol-1-ylpropyl)-3-[3-(3-methoxyphenyl)-1-phenylpyrazol-4-yl]prop-2-enamide | (E)-2-cyano-N-[3-(1-imidazolyl)propyl]-3-[3-(3-methoxyphenyl)-1-phenyl-4-pyrazolyl]-2-propenamide | MLS000589089 | SMR000219673 | cid_5940104
Type:
Small organic molecule
Emp. Form.:
C26H24N6O2
Mol. Mass.:
452.5078
SMILES:
COc1cccc(c1)-c1nn(cc1\C=C(/C#N)C(=O)NCCCn1ccnc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: