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Reaction Details
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TargetThrombin
LigandBDBM40950
Substrate/Competitorn/a
Meas. Tech.Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50>100000±0 nM
Citation PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
Thrombin
Name:Thrombin
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | Prothrombin | Thrombin heavy chain | Thrombin light chain
Type:Enzyme
Mol. Mass.:70502.73
Organism:Bos taurus (Bovine)
Description:P00735
Residue:625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERE
CLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGN
VSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRRE
ECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSS
EQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDL
GDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFE
SYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNF
TVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDY
IHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCK
ASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRD
GKYGFYTHVFRLKKWIQKVIDRLGS
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  Blast E-value cutoff:
BDBM40950
NameBDBM40950
Synonyms:3-[[2-(3,4-dihydro-2H-quinolin-1-yl)-1-oxoethyl]amino]-5-methyl-1H-indole-2-carboxylic acid methyl ester | 3-[[2-(3,4-dihydro-2H-quinolin-1-yl)acetyl]amino]-5-methyl-1H-indole-2-carboxylic acid methyl ester | MLS000037385 | SMR000039899 | cid_658948 | methyl 3-[2-(3,4-dihydro-2H-quinolin-1-yl)ethanoylamino]-5-methyl-1H-indole-2-carboxylate | methyl 3-[[2-(3,4-dihydro-2H-quinolin-1-yl)acetyl]amino]-5-methyl-1H-indole-2-carboxylate
TypeSmall organic molecule
Emp. Form.C22H23N3O3
Mol. Mass.377.4363
SMILESCOC(=O)c1[nH]c2ccc(C)cc2c1NC(=O)CN1CCCc2ccccc12
Structure
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n/a