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TargetTPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
LigandBDBM89099
Substrate/Competitorn/a
Meas. Tech.SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50>99000±n/a nM
Citation PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Name:TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:23245.32
Organism:Saccharomyces cerevisiae S288c
Description:gi_285814664
Residue:222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHP
LAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQG
LQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIG
AGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
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  Blast E-value cutoff:
BDBM89099
NameBDBM89099
Synonyms:2-[(3-chloranylpyridin-2-yl)sulfonylmethyl]-7-methyl-pyrido[1,2-a]pyrimidin-4-one | 2-[(3-chloro-2-pyridinyl)sulfonylmethyl]-7-methyl-4-pyrido[1,2-a]pyrimidinone | 2-[(3-chloro-2-pyridyl)sulfonylmethyl]-7-methyl-pyrido[1,2-a]pyrimidin-4-one | 2-[(3-chloropyridin-2-yl)sulfonylmethyl]-7-methylpyrido[1,2-a]pyrimidin-4-one | MLS-0463367.0001 | cid_47024356
TypeSmall organic molecule
Emp. Form.C15H12ClN3O3S
Mol. Mass.349.792
SMILESCc1ccc2nc(CS(=O)(=O)c3ncccc3Cl)cc(=O)n2c1
Structure
n/a